VIB-UGent Center for Inflammation Research
October 15, 2021
The Data Mining and Modeling for Biomedicine group (headed by Yvan Saeys) at the VIB Center for Inflammation Research and Ghent University is located in the historical city of Ghent, Belgium. The Saeys lab is at the forefront of computational method development in single-cell omics and has a longstanding collaboration with many wet labs in immunology, oncology, and plant biology. Recently, the lab has started a single-cell facility with advanced access to the newest single-cell multi-omics technologies (scRNA-seq, scATAC-seq, CITE-seq, and spatial proteomics and transcriptomics). A major focus of the lab is to model the dynamics of biological systems and characterize their underlying gene regulatory networks. To this end, the lab develops new computational machine learning methods to improve the current state-of-the-art.
The successful candidate will be responsible for developing novel methods (including trajectory inference and gene regulatory network inference) on single-cell omics data. The current position is part of a collaboration with BASF, a leading company in the plant biotechnology field, and the lab of Bert De Rybel at the VIB Center of Plant Systems Biology.
September 8, 2021
September 30, 2021
Institute of Biology Leiden, Leiden University
Plant diseases occur everywhere and are one of the major threats to our agriculture. Understanding how disease resistance works is one of the long-term missions in the newly established group led by Dr. Ding, and also the key to protecting plant health.
The PhD project will focus on investigating gene regulatory mechanisms involved in immunity activated by intracellular nucleotide-binding leucine-rich-repeat (NB-LRR) receptors (NLRs). This research will continue on the recent discovery that NLR-activated transcription in-part potentiated the cell-surface receptor-mediated immunity (Ngou et al. Nature 2021; Ding et al. JXB 2021).